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Breeding
The genomic breeding values
for Bernes Mountain Dogs
Details und Procedere

Introduction of genomic tests for longevity, hip dysplasia and elbow dysplasia of Bernese mountain dogs by the Schweizer Sennenhund-Verein für Deutschland e. V. (SSV) in cooperation with the foundation Hannover (TiHo). Blood samples can be tested from now on.

Norbert Bachmann, Christel Fechler und Ottmar Distl

Introduction

Durability is a genetic determinated attribute. This is proved for humans and animals. For humans an extreme old age is related to gene variants and probably stronger genetically influenced than an average lifespan. DNA repair genes and genes which have a bearing on cell growth as well as certain metabolic processes have a vital influence on reaching an old age. Those genes enable a high age with minor diseases because of the buffering of defect variants. This is the reason why a breeders approach to raise the longevity of Bernese mountain dogs by a positive selection of dogs with an old age and without major diseases is feasible. With the project “high life expectancy of Bernese mountain dogs” a genomic test was evolved which is placed at the disposal of breeders.

Procedure of the genomic test

The genomic test can only happen with EDTA blood samples which were sent in or already stored by the SSV at the foundation veterinary school Hannover. The genomic test is available for ever Bernese mountain dog from Germany or foreign countries. Members of the SSV get special conditions for the genomic test. For SSV dogs with already stored EDTA blood samples an examination request without blood sample is enough. A detailed leaflet provides information about every single step of the examination and the interpretation of the results. The genomic test costs 230 € and for SSV members 180 € per animal. The processing happens by the SSV. In case of any queries please contact Dr. Norbert Bachmann the project head of the genomic test for Bernese mountain dogs. The accomplishment and evaluation of the test take about four to six months. The results are sent to the submitter in written form. For each sample of a Bernese mountain dog the owner receives a genomic breeding value for longevity, hip dysplasia and elbow dysplasia. The genomic breeding values are profiles of about 100.000 genetic variants compiled for the characteristics longevity, hip dysplasia and elbow dysplasia for Bernese mountain dogs.

Longevity

Dogs with a genomic breeding value for longevity of around 100 carry cohesive bandages for an average age of 8 years. Dogs with cohesive bandages for an old age have genomic breeding values of over 110 and those with cohesive bandages for a short life have a genomic breeding value of under 90. The genomic breeding values constitute the average expectations of the genotyping result and therefore the value of individual animals can differ from the expected value. The reliability of the genomic breeding value for longevity is 70%

Hip dysplasia

Dogs with a genomic breeding value for hip dysplasia of about 85 carry cohesive bandages which are normally carried by Bernese mountain dogs without hip dysplasia. Dogs with a minor susceptibility for hip dysplasia have a genomic breeding value of under 75 and dogs with cohesive bandages for a high susceptibility for hip dysplasia have a genomic breeding value of over 95. The genomic breeding values constitute the average expectations of the genotyping result and therefore the value of individual animals can differ from the expected value. The reliability of the genomic breeding value for hip dysplasia is 85%.

Elbow dysplasia

Dogs with a genomic breeding value for elbow dysplasia of about 85 carry cohesive bandages which are normally carried by Bernese mountain dogs without elbow dysplasia. Dogs with a minor susceptibility for elbow dysplasia have a genomic breeding value of under 75 and dogs with cohesive bandages for a high susceptibility for elbow dysplasia have a genomic breeding value of over 95. The genomic breeding values constitute the average expectations of the genotyping result and therefore the value of individual animals can differ from the expected value. The reliability of the genomic breeding value for elbow dysplasia is 85%

Execution of the genomic selection for longevity in the SSV

The genomic breeding values for longevity are only for the breeding planning and not for an individual forecast of the age of a dog. Environmental incidents can influence the lifespan of a dog in a positive or negative way and are not predictable. The introduction of the genomic breeding values in the breeding planning consists of three phases. Initially there will be a “voluntary” phase. This time is to learn about the system. It is recommended that as many breeders as possible let their dogs get tested and use the gained information on their breeding decisions. The duration of this period is planned to be six to eight months. Afterwards breeders, breeding committee and the general assembly are up to decide about further strategies based on the experiences of the first phase. There will be no minimum values for the genomic breeding value. Every breeder shall decide on his own which course he/she wants to follow. It is recommended to choose the mating partners in order to keep the width of the breed because the selection is most successful with small, continuous steps. The aim is to higher the average lifespan for Bernese mountain dogs through mate selection.

For Bernese mountain dogs with certain characteristics the genotyping and/or *pathological - histological examinations (post mortem) can be made for free in restricted numbers. Those characteristics are:

Bernese mountain dogs with a proven age of 12 or more years

Bernese mountain dogs which had to be euthanised with an age under five years*

Bernese mountain dogs with a proven histiocytic sarcoma (malignant histiocytosis, MH)

Bernese mountain dogs with HD D or HD E

Bernese mountain dogs with ED-grade III or FPC (fragmented Processus Coronoideus)

Bernese mountain dogs with massive glomerulonephritis (inflammation of the renal corpuscles)*

Dogs with suspected degenerative Myelopathie (DM)*

For inspection of the medical findings and selection of the dogs please contact Dr. Norbert Bachmann bachmann@ssv-ev.de, phone: +49 (0)5753/ 92002

  

Progress in the genomic selection for a higher life expectation of Bernese mountain dogs

Ottmar Distl, Norbert Bachmann, Christel Fechler

Institute for Animal Breedings and Genetics,

Foundation veterinary school Hannover (TiHo), Bünteweg 17p, 30559 Hannover

Schweizer Sennenhund Verein Deutschland e.V.

Age and life expectation are vastly influenceable characteristics. An experimental verification of genetic variants for lifespan could be made using biotechnologically modified mice. A certain gene was implanted with a protective effect on chromosomes. Compared to the untreated control animals the transgene mice had a significant longer life. For humans the age has a substantial component and reaching an average lifespan has a heritability of h2 = 0,25. It is supposed, that an extreme high age is even stronger connected to hereditary influences with a heritability of h2 = 0,3 – 0,5. In the project “long-lived Bernese mountain dog” the heredity for lifespan was determined with a statistical procedure. The method was corrected for incomplete data of living dogs and all relatives were considered. For the complete data set of more than 8000 SSV Bernese mountain dogs born between 1995 and 2007 a heritability of h2 = 0,32 was estimated. The margin of error was around 0,035 which supports the breeding program for longevity of the SSV.

So far almost 450 Bernese mountain dogs were genotyped on the Illumina High Density Beadchip with over 173.000 SNPs (single nucleotide polymorphisms). The longevity is mainly influenced by nine different loci. Those loci involve a higher number of SNPs and therefore it is supposed that there is a higher count of gene variants with an influence on lifespan, too. Dogs with a high life expectation have a higher number of those chromosome sections with gene variants for a high life expectation. The aim is it to sift out these dogs to improve the breeding program. Therefore as many breeders as possible should specify the genomic breeding value for their dogs.

Based on 200 Bernese mountain dogs a SSV-Pretest for the histiocytic sarcoma was developed. At least five Loci are important for the histiocytic sarcoma. The SSV- Pretest (SSV-PHS) is available for everyone who requested the genomic breeding value at the SSV. Four classes from A-D are differentiated. A means a very low risk, B means a low risk, C a possible risk and D a danger for histiocytic sarcoma. According to present knowledge dogs with the result D should not be taken out of the breeding but be mated with dogs with an A or B result. The genomic breeding values for longevity are correlated with the SSV-Pretest genomic breeding value for the histiocytic sarcoma but are not identical. The histiocytic sarcoma is not the only cause of death for Bernese mountain dogs and there are a few dogs with an histiocytic sarcoma – probably because of a highly developed immunological respons – who reached an old age. Therefore it is necessary to regard the genomic breeding value for longevity. Dogs with proven histiocytic sarcoma can be tested for free. The breeders  are expressly requested to submit their veterinary history together with the examination application to the

Institute for Animal Breedings and Genetics, Foundation veterinary school Hannover”.

 

Procedure:

After requesting the genomic breeding value you will receive the genomic breeding values for longevity, elbow dysplasia, hip dysplasia and the results of the SSV-pretest within six months.

- Einsendebogen

- Merkblatt

- Allgemeine Informationen

Ansprechpartner/ Contacts

Versand der Proben an/

Send your samples to:

Prof. Dr. Ottmar Distl

SSV-Genomtest

Institut für Tierzucht und Vererbungsforschung

Stiftung Tierärztliche Hochschule Hannover

Bünteweg 17p

30559 Hannover

Telefon : 0511- 953-8876

Fax: 0511-953-8582

E-Mail: ABGLab@tiho-hannover.de

Hinweis: Bitte Email Adresse angeben, falls vorhanden/ Reference:Please write your e-mail address

Rückfragen/Questions:

Dr. med. vet. Norbert Bachmann

SSV- Projektleiter, Genomtest beim Berner Sennenhund

Hülsenbrink 14

31749 Auetal

Telefon:05753-92002

(Beste Erreichbarkeit: Montag bis Freitag 13-14 Uhr)

Fax: 05753-92001

E-Mail: bachmann@ssv-ev.de

 

Der Test beinhaltet/ the genomic test includes: :
1. genomischer Zuchtwert Langlebigkeit/ genomic breeding value -longevity

2. genomischer Zuchtwert Ellbogendysplasie/ genomic breeding value –elbow dysplasia

3. genomischer Zuchtwert Hüftgelenksdysplasie/

genomic breeding value –hipdysplasia

4. SSV-Pretest auf histiozytäres Sarkom/  SSV-pretest for HS

5. Degenerative Myelopathie Exon1 test

Kosten/ Prices for (1.-5.)

-180,00 Euro für Hunde im Besitz von SSV-Mitgliedern/ SSV members’dogs

-230,00 Euro für alle anderen Hunde/ other dogs

6. in addition (if desired) Degenrative Myelopathie Exon 2 test

additional costs :50,00 Euro

(this test is handled by SSV over Laboklin)

Kontoverbindung:

Schweizer Sennenhund-Verein

KTN: 313267379        

BLZ: 25551480

SPK. Schaumburg

Stichwort „Genomtest/ Name des Hundes/ Zuchtbuchnummer“

Please state „Genomtest/ Name of dog/ Registration number“

BIC-/SWIFT-Code: NOLADE21SHG

IBAN: DE13 2555 1480 0313 2673 79

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